Skip to main content
. 2019 Aug 22;15(8):e1006661. doi: 10.1371/journal.pcbi.1006661

Fig 1. Schematic diagram of Ca2+ dynamics described by the model.

Fig 1

The ER releases Ca2+ to the cytosol and MAM; the fluxes are denoted as JIPR and JnIPR, respectively. The cytosolic Ca2+ is pumped back into the ER lumen via SERCA (JSERCA), and the Ca2+ in MAM are also pumped back into the ER (JnSERCA). Mitochondria uptake Ca2+ from the cytosol (JMCU) and MAM (JnMCU), and mitochondrial Ca2+ is exchanged with Na+ in the cytosol (JNCX) and MAM (JnNCX). Ca2+ can freely diffuse between the cytosol and MAM (Jdiff). The total Ca2+ concentration is regulated by the plasma membrane influx (Jin) and efflux (Jpm).