Fig 12. Effects of decreased net SERCA flux on the steady state Ca²⁺ concentrations and Ca²⁺ oscillations.

Ca²⁺ concentrations in (A) the cytosol and (B) the ER at the steady state, P_s = 0 μM, simulated from the control model (in blue) and the model with increased $\overline{k}$ (in red). Oscillations of (C) cytosolic, (D) mitochondrial Ca²⁺ concentrations generated from the control model, in blue, and with the increased $\overline{k}$, in red dashed. The model was given continuous stimulation of IP₃ with P_s = 0.3 μM.