(A-B) 24-hour activity plots at endpoint from an implanted accelerometer (C) Mean 24-hour activity at endpoint (250.9±28.3au PBS, 380.1±11.8au TBX18,p=0.006) (D) Frequency of burst activity (6±0.8 episodes PBS, 16±0.9 episodes TBX18, p<0.001) (E) the duration of burst activity (96.2±14.3s PBS, 198.3±7s TBX18, p<0.001), and (F) and the latency period between bursts of activity was superior in TBX18 pigs (69.2±2.8min PBS, 48.3±2.7min TBX18, p<0.001).