Extended Data Table 2. Genetic correlations between neurodevelopmental disorder risk and a range of traits, calculated using the LD score method.

Trait 2	Genetic correlation between developmental disorder risk and trait 2	Standard error	95% confidence interval (standard error) lower bound	95% confidence interval (standard error) upper bound	P-value	SNP heritability for trait 2a	SE for trait 2 SNP heritability	Population prevalence used for liability scale conversion	N for trait 2 GWAS (Ncases:Ncontrols if dichotomous)
Years of schooling	-0.491	0.079	-0.336	-0.645	5.31x10-10	0.112	0.004		766,345
Intelligence (Spearman's g)	-0.441	0.104	-0.237	-0.645	2.15x10-5	0.203	0.013		78,308
Schizophrenia	0.279	0.066	0.148	0.409	2.71x10-5	0.242	0.008	0.01	11,260:24,542
Attention deficit hyperactivity disorder	0.727	0.292	0.155	1.299	0.013	0.071	0.031		17,666
Major depressive disorder	0.389	0.177	0.042	0.736	0.028	0.087	0.017	0.15	9,240:9,519
Childhood IQ	-0.252	0.153	0.048	-0.553	0.1	0.279	0.051		12,441
Autism spectrum disorder	-0.078	0.103	0.123	-0.28	0.445	0.118	0.01	0.012	18,381:27,969
Bipolar disorder	0.033	0.105	-0.172	0.238	0.751	0.25	0.023	0.01	7,481:9,250
Height	-0.176	0.07	-0.038	-0.314	0.012	0.336	0.021		253,288
Body mass index	0.174	0.071	0.035	0.312	0.015	0.189	0.01		336,107
Child birth length	-0.291	0.155	0.013	-0.595	0.061	0.165	0.027		28,459
Intracranial volume	-0.319	0.218	0.107	-0.746	0.142	0.167	0.053		11,373
Birth weight	-0.133	0.098	0.059	-0.326	0.174	0.095	0.008		143,677
Alzheimer's disease	0.424	0.259	-0.083	0.932	0.101	0.068	0.013	0.05	17,008:37,154
Coronary artery disease	0.077	0.091	-0.101	0.254	0.396	0.07	0.005	0.05	60,801:123,504
Lumbar Spine bone mineral density	0.101	0.132	-0.158	0.36	0.447	0.116	0.018		44,731
Parkinson's disease	0.093	0.136	-0.173	0.359	0.494	0.167	0.05	0.002	1,713:3,978
Type 2 Diabetes	0.071	0.122	-0.168	0.309	0.562	0.12	0.147	0.015	12,171:56,862
Crohn's disease	-0.024	0.096	0.164	-0.211	0.804	0.252	0.027	0.003	5,956:14,927

Trait 2 is the trait that neurodevelopmental disorder risk is compared to. Uncorrected P-values are from a two-sided z-score.

^aSNP heritability for dichotomous traits is on the liability scale.