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. Author manuscript; available in PMC: 2020 Sep 4.
Published in final edited form as: ChemMedChem. 2019 Jul 24;14(17):1597–1603. doi: 10.1002/cmdc.201900344

Table 3.

Determination of relative prodrug efficiencies.[a]

Compound k1 α R2
2[11] −5.2 4.7 0.97
3[11] 0.96 0.84 1.0
4[11] −1.3 1.8 0.97
5[11] −1.7 2.4 0.98
12[11] −2.6 2.6 0.90
14 −1.8 2.2 1.0
17 2.2 2.2 0.97
[a]

Data represent the values determined from the mean of three independent experiments.