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. Author manuscript; available in PMC: 2020 Oct 15.
Published in final edited form as: Dev Biol. 2019 Jun 14;454(2):181–189. doi: 10.1016/j.ydbio.2019.06.007

Figure 2. The signaling abilities of Sev/DER chimerical receptors.

Figure 2

(A) The sev.SSD chimera (Sev ICD replaced with that of DER and expressed under sev transcriptional control) rescues R7s in all sev° ommatidiaatidia in adult eyes. (B) When the DER TM domain was additionally substituted and expressed under sev transcriptional control (sev.SDD) in two copies in sev°, occasional supernumerary R7s are detected (horizontal red arrow). (C) sev.SSD rescues R7s specification at the correct time and place in sev° eye discs. (D) A wild type eye disc stained with anti-DER.ICD shows staining in all cells with an upregulation in cells in and behind the morphogentic furrow. (E) sev°; sev.SSD eye discs stained with α-DER.ICD show strong upregulation in the Sev-expressing cells. (F) High magnification from image in E showing DER expression in the normal Sev pattern.