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. Author manuscript; available in PMC: 2020 Oct 15.
Published in final edited form as: Dev Biol. 2019 Jun 23;454(2):156–169. doi: 10.1016/j.ydbio.2019.06.012

Fig. 2: Adamts18−/− lungs are smaller with disoriented branches compared to wildtype counterparts at embryonic and adult stages.

Fig. 2:

A: A schematic of the Adamts18 knockout mouse acquired from KOMP showing the deleted region and homologous recombination to insert a LacZ sequence in its place (adapted from KOMP’s description of the mouse). B: The genotyping results of pups born from Adamts18+/− crosses demonstrating Mendelian inheritance of the wildtype, Adamts18+/−, and Adamts18−/− genotypes (numbers on bar graph represent the number counted). C-J: Wildtype (C, E, G, I) and Adamts18−/− (D, F, H, J) lungs at various stages stained with cytokeratin. The 5 lung lobes are highlighted in C and D: cranial = green, medial = pink, caudal = yellow, accessory = purple, left = blue. K, L: Freshly dissected wildtype (K) and Adamts18−/− (L) adult lungs. Line = 500μm.