Table 1.
Leukemic cell lines used in this study
| Human leukemia cell line |
P53 response to irradiation |
P53 status | BCR-ABL status |
Source ATCC |
|---|---|---|---|---|
| JM1 (B-ALL) | Yes | Wild type | None | CRL-10423 |
| SB (B-ALL) | Yes | Wild type | None | CCL-120 |
| MUTZ5 | Yes | Wild type | Ph-like | |
| MHH-CALL4 | Yes | Wild type | Ph-like | |
| Nalm6 (B-ALL) | Yes | Wild type | Ph+ | CRL-3273 |
| Nalm1(B-ALL) | NA | Wild type | Ph+ | CRL-1567 |
| Sup B15(B-ALL) | NA | Wild type | Ph+ | CRL-1929 |
| CEM(T-ALL) | No | Multiple mutation | NA | CCL-119 |
| SupT1(T-ALL) | Yes | Wild type | NA | CRL-1942 |
| Molt4(T-ALL) | Yes | Wild type | NA | CRL-1582 |
| Jurkat(T-ALL) | Weaker | Multiple mutation | NA | TIB-152 |
| HL60 (AML) | No | Null | NA | CCL-240 |
| Reh | Yes | Wild type | NA | CRL-8286 |
| HS5 | NA | Bone marrow fibroblast | NA | CRL-11882 |
Note: Finger printed positive cell lines with mycoplasma negative status were used within 20 passages from thawing. P53 protein expression in response to gamma-irradiation (800 rads) was confirmed by using cytometry (L.S. Golfman; unpublished observation). Wild-type p53 status was verified by sequencing or querying in the COSMIC database and/or searching the literature. NA: not applicable for irradiation/BCR-ABL studies performed.