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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Biotechnol Bioeng. 2019 Jul 21;116(10):2439–2450. doi: 10.1002/bit.27092

Table 3:

Amino acid substitutions of the three PrAMPs in the multisubstitution library based on improved MIC values against E. coli strain JW0013 as monosubstitutions

Api_WT G N N R P V Y I P Q P R P P H P R L
Api_R4K/I8K G N N K P V Y K P Q P R P P H P R L
Api_R4K/I8R G N N K P V Y R P Q P R P P H P R L
Api_R4K/H15R G N N K P V Y I P Q P R P P R P R L
Api_I8K/H15R G N N R P V Y K P Q P R P P R P R L
Api_I8R/H15R G N N R P V Y R P Q P R P P R P R L
Api_R4K/I8K/H15R G N N K P V Y K P Q P R P P R P R L
Api_R4K/I8R/H15R G N N K P V Y R P Q P R P P R P R L
Pyr_WT V D K G S Y L P R P T P P R P I Y N R N
Pyr_L7K/R14K V D K G S Y K P R P T P P K P I Y N R N
Pyr_L7R/R14K V D K G S Y R P R P T P P K P I Y N R N
Bac_WT R R I R P R P P R L P R P R P R
Bac_R4K/P5K R R I K K R P P R L P R P R P R
Bac_R4K/R16K R R I K P R P P R L P R P R P K
Bac_P5K/R16K R R I R K R P P R L P R P R P K
Bac_R4K/P5K/R16K R R I K K R P P R L P R P R P K