Table 5:

Antimicrobial activity of the most potent PrAMPs derivatives against some strains of the Gram-negative bacteria E. coli and S. Typhimurium in 12.5% MHB. The values indicate the mode ± the uncertainty. The MIC values that are at least 2 times smaller than the wild-type are shown in bold. The MIC values are in μmol/L.

	Commensal E. coli			Salmonella
Peptides	FVEC 638	FVEC 964	PUTI 379	Tennessee	Newport	Infantis #129 B
Api_WT	0.048 ± 0.011	0.048 ± 0.011	0.048 ± 0.011	0.048 ± 0.011	0.031 ± 0.014	0.048 ± 0.011
Api_R4K/I8K	0.048 ± 0.011	0.048 ± 0.011	0.048 ± 0.011	0.024 ± 0.006*	0.024 ± 0.006	0.024 ± 0.006*
Api_R4K/I8R	0.048 ± 0.011	0.048 ± 0.011	0.048 ± 0.011	0.024 ± 0.006*	0.017 ± 0.009	0.024 ± 0.006*
Pyr_WT	>0.416	>0.600	>0.600	>0.600	>0.416	>0.600
Pyr_L7K/R14K	0.197 ± 0.088*	0.300 ± 0.070*	0.300 ± 0.070*	0.300 ± 0.070*	0.075 ± 0.018*	0.300 ± 0.070*
Pyr_L7R/R14K	0.150 ± 0.034*	0.150 ± 0.034*	0.208 ± 0.106*	0.075 ± 0.018*	0.037 ± 0.008*	0.098 ± 0.045*

^*denotes p<0.05