. Author manuscript; available in PMC: 2020 Oct 1.

Published in final edited form as: Biotechnol Bioeng. 2019 Jul 21;116(10):2439–2450. doi: 10.1002/bit.27092

Table 7:

Antimicrobial activity of multisubstituted PrAMPs derivatives against strain BW25113 in 5% M9 and 20% M9 growth media. The values indicate the mode ± the uncertainty. The MIC values are in μmol/L. The MIC values that are at least 2 times smaller than the wild-type are shown in bold.

	E. coli BW25113

Peptides	5% M9	20% M9
Api_WT	0.384 ± 0.080	>0.384
Api_R4K/I8R	0.192 ± 0.044^*	0.384 ± 0.080^*
Pyr_WT	0.300 ± 0.070	>0.600
Pyr_L7R/R14K	0.150 ± 0.034^*	0.300 ± 0.070^*

denotes p<0.05