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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2019 Jun 21;1866(11):118496. doi: 10.1016/j.bbamcr.2019.06.010

Figure 4.

Figure 4

Formation of linear clusters of DDR1b and DDR2 in response to collagen fibrils. The collagen fibrils serves as a multivalent ligand and likely recruits both monomers and dimers of DDRs. The DDRs thus assemble together along the fibril length to form filamentous structures or linear clusters. These assemblies can be homo-oligomers or hetero-oligomers. Receptor phosphorylation (at Y513) in IJXM for DDR1b and (at Y793 for DDR1 and Y740 for DDR2) in KD occurs upon formation of linear clusters due to trans-phosphorylation leading to canonical DDR signaling. Formation of these linear clusters is likely mediated by several domains including the ECD, TMD, IJXM and KD. All DDR1 isoforms as well as DDR1-ΔECD could putatively participate in formation of linear clusters.