Table 2.
Associations between individual miRNA and breast cancer outcomes+ in the WHEL-genomics breast cancer study (N = 1253)
| Disease-free survival (# of events 303) | Breast cancer survival (# of events 219) | Overall survival (# of events 316) | ||||
|---|---|---|---|---|---|---|
| miRNA | HR (95% CI) | P Valuea | HR (95% CI) | P Valuea | HR (95% CI) | P Valuea |
| 93.5p | 1.07 (0.96, 1.19) | 0.202 | 1.1 (0.96, 1.25) | 0.169 | 1.04 (0.95, 1.15) | 0.381 |
| 150.5p | 0.94 (0.87, 1.01) | 0.072 | 0.91 (0.84, 0.99) | 0.025 | 0.93 (0.87, 0.99) | 0.033 |
| 128.3p | 1 (0.94, 1.08) | 0.903 | 1.03 (0.94, 1.13) | 0.531 | 1.01 (0.94, 1.08) | 0.850 |
| 141.3p | 1.07 (0.97, 1.19) | 0.160 | 1.11 (0.99, 1.26) | 0.079 | 1.08 (0.98, 1.19) | 0.127 |
| 21.5p | 1.04 (0.93, 1.17) | 0.486 | 1.14 (0.98, 1.31) | 0.083 | 1.06 (0.94, 1.18) | 0.336 |
| 1246 | 1.12 (0.98, 1.28) | 0.101 | 1.03 (0.88, 1.2) | 0.722 | 1.06 (0.93, 1.22) | 0.353 |
| 16.5p | 1.11 (0.99, 1.25) | 0.082 | 1.18 (1.02, 1.37) | 0.028 | 1.12 (1, 1.26) | 0.057 |
| 205.5p | 0.96 (0.91, 1.02) | 0.173 | 0.93 (0.88, 0.99) | 0.021 | 0.95 (0.9, 1) | 0.056 |
| 342.3p | 0.98 (0.89, 1.07) | 0.649 | 1 (0.89, 1.12) | 0.949 | 1.01 (0.92, 1.1) | 0.862 |
| 29c.3p | 1.09 (0.97, 1.21) | 0.139 | 1.2 (1.05, 1.37) | 0.009 | 1.19 (1.07, 1.33) | 0.002b |
| 27b.3p | 1.13 (1.01, 1.27) | 0.037 | 1.2 (1.04, 1.38) | 0.012 | 1.05 (0.95, 1.17) | 0.326 |
| 187.3p | 1.03 (0.96, 1.11) | 0.348 | 1.08 (0.99, 1.17) | 0.085 | 1.09 (1.01, 1.17) | 0.021 |
| 26b.5p | 1.03 (0.89, 1.2) | 0.695 | 1.08 (0.9, 1.3) | 0.393 | 1.05 (0.91, 1.22) | 0.508 |
| 15a.5p | 1.06 (0.92, 1.22) | 0.449 | 1.08 (0.9, 1.29) | 0.423 | 1.08 (0.93, 1.24) | 0.301 |
| 221.3p | 1.09 (1, 1.19) | 0.062 | 1.1 (0.99, 1.23) | 0.071 | 1.01 (0.93, 1.09) | 0.809 |
| 494.3p | 0.95 (0.84, 1.09) | 0.497 | 0.93 (0.8, 1.09) | 0.390 | 0.99 (0.87, 1.12) | 0.845 |
| 30c.5p | 1.05 (0.95, 1.16) | 0.374 | 1.01 (0.9, 1.14) | 0.868 | 0.99 (0.9, 1.08) | 0.743 |
| 769.5p | 0.97 (0.88, 1.06) | 0.489 | 1.01 (0.9, 1.13) | 0.873 | 1.01 (0.92, 1.11) | 0.830 |
| 210.3p | 1.1 (1.01, 1.2) | 0.027 | 1.06 (0.96, 1.18) | 0.226 | 1.04 (0.96, 1.13) | 0.375 |
| 10b.5p | 1.07 (0.98, 1.16) | 0.138 | 1.1 (0.99, 1.23) | 0.065 | 1.05 (0.96, 1.14) | 0.286 |
| 143.3p | 1.23 (1.08, 1.41) | 0.002b | 1.28 (1.1, 1.51) | 0.002b | 1.14 (1, 1.3) | 0.046 |
| 7.5p | 1.03 (0.96, 1.11) | 0.392 | 0.99 (0.91, 1.08) | 0.772 | 1.02 (0.96, 1.1) | 0.490 |
| 200b.3p | 1.04 (0.94, 1.15) | 0.426 | 1.08 (0.95, 1.22) | 0.250 | 1.08 (0.97, 1.2) | 0.142 |
| 135a.5p | 0.98 (0.94, 1.02) | 0.315 | 0.99 (0.94, 1.04) | 0.595 | 0.98 (0.94, 1.03) | 0.480 |
| 126.3p | 1.06 (0.95, 1.2) | 0.307 | 1.11 (0.96, 1.3) | 0.166 | 1.01 (0.9, 1.12) | 0.922 |
+
adjusted for tumor stage, tumor grade, age at diagnosis
a
p-values are not adjusted for multiple comparisons
b
statistically significant after Bonferroni adjustment for 25 miRNAs