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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Mol Cancer Ther. 2019 Jul 3;18(9):1637–1648. doi: 10.1158/1535-7163.MCT-18-1056

Fig 3. Modeling of tumor volume using in vivo ERK½ pathway activation.

Fig 3.

(A-B) 1205LuTR reporter xenografts were treated continuously (n=9) for 84 days or intermittently (n=10) on a one week on, one week off cycle until day 42. Intermittently treated mice were switched to continuous dosing on day 42. Bar graph represents average tumor volume up to day 42. After day 42 data, are presented as a line graph for individual mice. (C-E) Average tumor volumes and luciferase intensity normalized to tumor volume during continuous (red), intermittent (blue), or intermittent switched to continuous (purple) treatment schemes. (F) Regression analysis of intermittent dosing as quantification for the association between firefly expression and tumor volume.