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. 2019 Sep 4;9:12780. doi: 10.1038/s41598-019-49146-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ROS contribute to but are insufficient for Ire1 activation upon diauxic shift. (a,b) IRE1+ cells were cultured in the presence or absence of 20 mM NAC and monitored for growth and HAC1-mRNA splicing. (c) IRE1+ cells were treated with ER-stressing chemicals as indicated and checked for HAC1-mRNA splicing. NAC and ER stressors were simultaneously added into cultures. (d) IRE1+ cells or cells carrying bZIP-Ire1 were treated with the indicated concentrations of hydrogen peroxide for 30 min or remained unstressed, and checked for HAC1-mRNA splicing.