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. 2019 Sep 4;10:3987. doi: 10.1038/s41467-019-11773-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — SENP6 demonstrates group deSUMOylation activity. a STRING network analysis of enriched proteins after SENP6 knockdown, with a STRING interaction confidence of 0.7 or higher. Cytoscape software was used to visualize the interaction network. Color and node size indicate the fold-change differences in abundance after SENP6 knockdown compared with the nontargeting control. b MCODE was used to extract the most highly interconnected clusters form the network shown in a. Cluster 1 contains multiple proteins involved in DNA damage response. c Cluster 2 includes multiple kinetochore and kinetochore-associated proteins. d Cluster 3 includes proteins that are involved in ribosomal RNA metabolism. e Cluster 4 contains proteins associated with DNA recombination and the SUMOylation pathway. f Gene Ontology (GO) enrichment analysis of SENP6-regulated proteins. The bar graph shows the most significantly overrepresented GO terms for biological processes (BP) in dark blue, molecular functions (MF) in purple, and cellular compartments (CC) in light blue compared against the annotated human proteome. Source data are provided as a Source Data file