Table 3.
Adverse events of any grade and grade ≥3 adverse events with an incidence of ≥20%
| Carfilzomib | ||||||||
|---|---|---|---|---|---|---|---|---|
| 15 mg/m2 | 20 mg/m2 | 20/27 mg/m2 | Total | |||||
| No. of patients | 4 | 6 | 40 | 50 | ||||
| All grades | Grade ≥3 | All grades | Grade ≥3 | All grades | Grade ≥3 | All grades | Grade ≥3 | |
| Hematological | ||||||||
| Lymphopeniaa | 3 (75.0) | 1 (25.0) | 6 (100.0) | 5 (83.3) | 34 (85.0) | 29 (72.5) | 43 (86.0) | 35 (70.0) |
| Thrombocytopenia | 0 | 0 | 4 (66.7) | 1 (16.7) | 30 (75.0) | 12 (30.0) | 34 (68.0) | 13 (26.0) |
| Neutropenia | 3 (75.0) | 1 (25.0) | 2 (33.3) | 2 (33.3) | 23 (57.5) | 16 (40.0) | 28 (56.0) | 19 (38.0) |
| Leukopenia | 2 (50.0) | 0 | 2 (33.3) | 1 (16.7) | 22 (55.0) | 13 (32.5) | 26 (52.0) | 14 (28.0) |
| Decreased hemoglobin | 1 (25.0) | 0 | 2 (33.3) | 1 (16.7) | 18 (45.0) | 11 (27.5) | 21 (42.0) | 12 (24.0) |
| Increased white blood cell count | 1 (25.0) | 0 | 3 (50.0) | 0 | 13 (32.5) | 0 | 17 (34.0) | 0 |
| Anemia | 0 | 0 | 0 | 0 | 12 (30.0) | 6 (15.0) | 12 (24.0) | 6 (12.0) |
| Increased neutrophil count | 0 | 0 | 2 (33.3) | 0 | 9 (22.5) | 0 | 11 (22.0) | 0 |
| Non‐hematological | ||||||||
| Increased serum creatinine | 2 (50.0) | 0 | 2 (33.3) | 1 (16.7) | 18 (45.0) | 2 (5.0) | 22 (44.0) | 3 (6.0) |
| Increased serum lactate dehydrogenase | 0 | 0 | 4 (66.7) | 1 (16.7) | 13 (32.5) | 0 | 17 (34.0) | 1 (2.0) |
| Hypophosphatemia | 0 | 0 | 1 (16.7) | 0 | 16 (40.0) | 3 (7.5) | 17 (34.0) | 3 (6.0) |
| Hyperglycemia | 2 (50.0) | 0 | 4 (66.7) | 2 (33.3) | 10 (25.0) | 1 (2.5) | 16 (32.0) | 3 (6.0) |
| Increased aspartate aminotransferase | 0 | 0 | 4 (66.7) | 2 (33.3) | 10 (25.0) | 3 (7.5) | 14 (28.0) | 5 (10.0) |
| Hypertensionb | 2 (50.0) | 0 | 2 (33.3) | 0 | 10 (25.0) | 5 (12.5) | 14 (28.0) | 5 (10.0) |
| Pyrexia | 0 | 0 | 2 (33.3) | 0 | 12 (30.0) | 2 (5.0) | 14 (28.0) | 2 (4.0) |
| Increased alanine aminotransferase | 0 | 0 | 3 (50.0) | 1 (16.7) | 10 (25.0) | 2 (5.0) | 13 (26.0) | 3 (6.0) |
| Nasopharyngitis | 0 | 0 | 1 (16.7) | 0 | 12 (30.0) | 0 | 13 (26.0) | 0 |
| Increased blood urea | 0 | 0 | 3 (50.0) | 0 | 9 (22.5) | 0 | 12 (24.0) | 0 |
| Malaise | 2 (50.0) | 0 | 2 (33.3) | 0 | 8 (20.0) | 0 | 12 (24.0) | 0 |
| Peripheral neuropathyc | 0 | 0 | 1 (16.7) | 0 | 8 (20.0) | 0 | 9 (18.0) | 0 |
Data are n (%).
a
Lymphopenia includes lymphopenia and decreased lymphocyte counts.
b
Hypertension includes hypertension and increased blood pressure.
c
Peripheral neuropathy includes peripheral neuropathy, peripheral sensory neuropathy, and trigeminal nerve disorder.