Figure 2.

Uridine‐cytidine kinase 2 (UCK2) is overexpressed in lung cancer. A, Analysis of UCK2 expression in normal lung and non‐small cell lung cancer (NSCLC) in GSE33532. ****P < .0001, unpaired t test. B,C, Analysis of UCK2 expression in normal lung and different pathological subtypes of lung cancer in GSE30219. ***P < .001, one‐way ANOVA followed by Dunnett's test. D, Oncomine datasets showing UCK2 expression in lung cancer; red denotes significant overexpression. E,F, UCK2 mRNA expression in 37 lung cancer tissues and adjacent nontumor tissues were explored by real‐time PCR. ***P < .001. G, UCK2 mRNA expression in human bronchial epithelial cell BEAS‐2B and lung cancer cell lines. ***P < .001. H, UCK2 expression in lung cancer patients with and without tobacco smoking history. ****P < .0001. I, UCK2 expression in EGFR‐mutated and EGFR nonmutated lung cancer tissue. **P < .01; ****P < .0001. ADC, adenocarcinoma; BAS, basaloid; CARCI, carcinoid tumor; LCC, large cell carcinoma; LCNE, large cell neuroendocrine tumor; SCC, squamous cell carcinoma; SCLC, small cell lung cancer