Table 4.
Hamilton Anxiety Rating Scale, subscores and selected items-meta-analysis results for change between baseline and treatment end (Silexan—placebo; pooled random effect)
| Outcome | N (Silexan/placebo) | I2 (%) | Mean value differencea (95% confidence interval) | p |
|---|---|---|---|---|
| Somatic anxiety (subscore) | 349/348 | 68.1 | − 1.70 (− 2.77; − 0.63) | 0.002 |
| Psychic anxiety (subscore) | 349/348 | 74.5 | − 2.15 (− 3.66; − 0.65) | 0.005 |
| Anxious mood (item) | 349/348 | 50.2 | − 0.43 (− 0.65; − 0.21) | < 0.001 |
| Tension (item) | 349/348 | 0.0 | − 0.38 (− 0.54; − 0.22) | < 0.001 |
| Insomnia (item) | 349/348 | 78.5 | − 0.38 (0.73; − 0.03) | 0.034 |
aNegative values favour Silexan