. 2017 Nov 17;269(2):183–193. doi: 10.1007/s00406-017-0852-4

Table 5.

Additional efficacy outcomes—meta-analysis results for change between baseline and treatment end (Silexan—placebo; pooled random effect)

Outcome	N (Silexan/placebo)	I² (%)	Mean value difference (95% confidence interval)	p
CGI item 1 (severity of impairment)^a	335/337	63.8	− 0.54 (− 0.85; − 0.23)	< 0.001
PSQI total score^a	190/192	26.9	− 1.36 (− 2.28; − 0.44)	0.004
SF-36 physical health subscore^b	252/256	0.0	7.32 (3.88; 10.77)	< 0.001
SF-36 mental health subscore^b	252/256	16.0	10.19 (5.78; 14.61)	< 0.001

CGI Clinical Global Impressions, PSQI Pittsburgh Sleep Quality Index, SF-36 SF-36 Health Survey Questionnaire

^aNegative values favour Silexan

^bPositive values favour Silexan