Fig. 10 .

The signaling pathway network of TSGA10 and HIF-1α proteins under the normoxia and hypoxia. In the cell under the normoxia, the prolyl hydroxylation pathway is activated and Von Hippel-Lindau tumor suppressor protein (pVHL) targets subunit α of HIF-1 protein that leads to the ubiquitin (Ub)-mediated HIF-1α degradation. PI3 kinase: Phosphoinositide 3-kinase; PI(4, 5)P2: Phosphatidylinositol 4,5-bisphosphate; PTEN: Phosphatase and tensin homolog; AKT (PKB): Protein kinase B; mTOR: mechanistic target of rapamycin; HIF-3α: hypoxia-inducible factor 3 alpha; CBP: CREB-binding protein; P300: histone acetyltransferase p300; HRE: hypoxia response element. The signaling pathway is reconstructed based on the BioModels and KEGG database and using the CellDesigner v4.4.0 in SBML format.