Table 3. The list of top 10 hubs obtained by employing the nine different types of scoring algorithms of CytoHubba plugin .

Rank	Scoring method									Consensus a
	Betweenness	MNC	Bottleneck	Radiality	EcCentricity	MCC	Stress	Closeness	Degree
1	HIF-1α	HIF1- α	HIF-1α	HIF-1α	TSGA10	VEGFA	HSP90AA1	HIF-1α	HIF-1α	HIF-1α
2	HSP90AA1	VEGFA	VEGFA	VEGFA	TEKT3	HIF-1α	HIF-1α	VEGFA	VEGFA	VEGFA
3	TSGA10	ARNT	HSP90AA1	ARNT	LOC81691	TP53	AKT1	ARNT	ARNT	HSP90AA1
4	AKT1	AKT1	TSGA10	HSP90AA1	SPAG6	AKT1	VEGFA	HSP90AA1	HSP90AA1	AKT1
5	ARNT	HSP90AA1	APP	AKT1	TUBA3C	JUN	ARNT	AKT1	AKT1	ARNT
6	VEGFA	TP53	TP53	TP53	BACE1	EP300	TSGA10	TP53	TP53	TP53
7	TUPA3C	VHL	SPAG6	JUN	HIF-1α	EGFR	APP	VHL	VHL	TSGA10
8	SPAG6	JUN	TUBB4B	EGFR	CXCR4	CDKN1A	VHL	JUN	JUN	VHL
9	APP	EGFR	AKT1	VHL	ADM	MDM2	NOTCH1	EGFR	EGFR	JUN
10	VHL	EPO	FLT1	EP300	BHLHE41	HSP90AA1	TP53	EP300	EPO	EGFR

MNC: maximum neighborhood component; MCC: maximal clique centrality.

^a The final consensus protein hubs are ranked as 1 (as the highest) to 10 (the lowest).