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. 2019 Sep 4;9:12788. doi: 10.1038/s41598-019-49163-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DNA opening angles are affected by mutation and histone H1 interaction. Normalized probabilities of the opening angles θ were plotted in 15° binned sectors for the different cases. The small example images in (a) represent nucleosome objects with the corresponding DNA opening angle. For each case, (a) wt, (b) wt +H1, (c) mut and (d) mut +H1 all opening angles are plotted (n_wt = 444, n_{wt +H1} = 445, n_mut = 444, n_{mut +H1} = 448). Diagrams for samples with histone H1 are shown in red. Linker histone H1 induces a distinct population between 60° and 90° in the distribution of the opening angle for wt. Compared to wt, mutated nucleosomes show higher opening angles.