Table 2.
Histone marks identified at the Myod proximal regulatory region (PRR), distal regulatory region (DRR) and core enhancer
| Region | Histone | Type of mark | Binding shown by | Comments | References |
|---|---|---|---|---|---|
| PRR | H3K4me3 | Active | ChIP-qPCR in Rhabdomyosarcoma cells | Taberlay et al. (2011) | |
| H3K27ac | Active | ChIP-qPCR in C2C12 cells | Levels increase as cells differentiate | Hamed et al. (2013) | |
| H4Kac | Active | ChIP-PCR in mouse embryo limbs | Lower levels than at CE | Havis et al. (2012) | |
| H3K9ac | Active | ChIP-qPCR in C2C12 cells | Levels increase as cells differentiate | Yang et al. (2011) and Hamed et al. (2013) | |
| H3.3 | Active | ChIP-qPCR in C2C12 cells | Lower levels than CE. Levels increase as cells differentiate | Yang et al. (2011) | |
| DRR | H3K4me3 | Active | ChIP-qPCR in C2C12 cells | Levels increase as cells differentiate | Yang et al. (2011) |
| H3K27ac | Active | ChIP-qPCR in C2C12 cells | Levels increase as cells differentiate | Hamed et al. (2013) | |
| H3K9ac | Active | ChIP-qPCR in C2C12 cells | Levels increase as cells differentiate | Yang et al. (2011) and Hamed et al. (2013) | |
| H3.3 | Active | ChIP-qPCR in C2C12 cells. | Lower levels than CE. Levels increase as cells differentiate | Yang et al. (2011) | |
| H3K20me2 | Repressive | ChIP-qPCR in satellite cells isolated from mouse muscle | Levels decrease in Suv4-20h1 knockout cells | Boonsanay et al. (2016) | |
| H3K9me2 | Repressive | ChIP-qPCR in C2C12 cells | Luo et al. (2017) | ||
| CE | H3K4me3 | Active | ChIP-qPCR in C2C12 cells | Levels increase as cells differentiate | Scionti et al. (2017) and Yang et al. (2011) |
| H3K27ac | Active | ChIP-qPCR in and differentiated C2C12 cells | Levels increase greatly as cells differentiate | Hamed et al. (2013) | |
| H4Kac | Active | ChIP-PCR in mouse embryo limbs | Higher levels than at PRR | Havis et al. (2012) | |
| H3K4me1 | Enhancer | ChIP-qPCR in Rhabdomyosarcoma cells | Taberlay et al. (2011) | ||
| H3K9ac | Active | ChIP-qPCR in C2C12 cells | Levels increase as cells differentiate. Levels decrease when MSX1 expressed | Yang et al. (2011), Hamed et al. (2013) and Lee et al. (2004) | |
| H3.3 | Active | ChIP-qPCR in C2C12 | Higher levels than DRR and PRR. Levels increase as cells differentiate | Yang et al. (2011) | |
| H3K9me2 | Repressive | ChIP-qPCR in C2C12 | Levels increase when MSX1 expressed. | Lee et al. (2004) | |
| HB1 | Repressive | ChIP-qPCR in C2C12 | Levels increase when MSX1 expressed | Lee et al. (2004) |