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Time‐dependent inhibition of enteropeptidase by SCO‐792. (A) Chemical structure of SCO‐792. (B) Percent inhibition is plotted as a function of inhibitor concentration at 10, 30, 60, and 120 minutes of incubation. (C) Enzyme progress curves were obtained at 16 different inhibitor concentrations. (D) Data from (C) were fit to Equation to determine observed rate constants (K obs). Replotting of K obs according to Equation yielded K inact/KI. The estimated K inact/KI was 82 000 (/mol/L s)
