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. 2019 Aug 5;20(9):e48891. doi: 10.15252/embr.201948891

Figure 1. IRF1 and IRF2 regulation of inflammasome components in humans and mice.

Figure 1

Cytosolic LPS, sensed by caspase‐4/‐5 in humans and caspase‐11 in mice, activates the non‐canonical inflammasome. This leads to the cleavage of gasdermin D and subsequent formation of pores in the plasma membrane. IRF2 transcription factor directly regulates the expression levels of gasdermin D in mouse macrophages and either gasdermin D or caspase‐4 in humans in a cell type‐specific manner. In the presence of IFN‐γ, IRF1 can compensate for IRF2 deficiency and induce caspase‐4 or gasdermin D expression.