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. 2019 Jul 24;20(9):e47250. doi: 10.15252/embr.201847250

Figure 1. Screening for DDR factors involved in R loop homeostasis.

Figure 1

  1. Top‐hit selected candidates are listed. The plot shows relative S9.6 nuclear intensity values for cells transformed with each of the indicated pool of siRNAs.
  2. Representative images of HeLa cells immunostained with S9.6 and nucleolin antibodies after transfection with at least a pool of two siRNAs of each original pool.
  3. Relative S9.6 signal intensity per nucleus after nucleolus signal removal in HeLa cells transfected with the indicated siRNAs. More than 250 total cells from three independent experiments were considered. The median of each population is shown. Boxes and whiskers indicate 25–75 and 10–90 percentiles, respectively. ***P < 0.001 (Mann–Whitney U‐test).