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. 2019 Jul 29;18:24–33. doi: 10.1016/j.omtn.2019.07.012

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Serum Exosomal Cdr1a Level Is Downregulated in Cisplatin-Resistant Ovarian Patients

(A) Representative image of exosome (indicated by red arrows) derived from serum of ovarian cancer patients detected from electron microscope. (B) The markers of exosome from purified serum exosome were analyzed by western blotting in exosomes (E) and exosome-depleted supernatant (EDS). (C) Quantitative real-time PCR for the abundance of Cdr1a in serum exosomes. The levels of Cdr1a in serum exosomes from the cisplatin-resistant group were significantly lower than from the cisplatin-sensitive group. (D) In the exosomes extracted from serum of ovarian cancer patients, the expression levels of Cdr1a were negatively correlated with that of miR-1270.