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. 2019 Aug 30;21(10):1015–1035. doi: 10.1016/j.neo.2019.07.011

Figure 4.

Figure 4

Correlation analysis of MCM2, MCM4, MCM6, and MKI67 in breast cancer patients.

(A) Correlation diagrams using MiSTIC visualization tool to correlate MCM2, MCM4, and MCM6 with MKI67 and ESR1 in breast cancers based on RNA-sequencing data derived from TCGA. A strong positive correlation could be detected between each of MCM2, MCM4, and MCM6 and MKI67 (r = 0.73, 0.66, and 0.73, respectively), whereas a negative correlation was observed between ESR1 and each of MCM2, MCM4, MCM6, and MKI67(r = −0.33, −0.34, −0.44, and −0.38, respectively). (B) Targeted correlation analysis of MCM2, MCM4, MCM6, and MKI67 in all breast cancer patients and within molecular subtypes as represented by bc-GenExMiner database v4.0. The correlation values were different within each molecular subtype.