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. 2019 Aug 30;21(10):1015–1035. doi: 10.1016/j.neo.2019.07.011

Figure 5.

Figure 5

Patterns of MCM2, MCM4, MCM6, and Ki-67 expression in normal breast tissue.

(A) A tissue core showing normal breast tissue and stained with HPS. (B) MCM2, MCM4, and MCM6 nuclear labeling in only a few scattered luminal cells lining the terminal duct lobular units was noticed in 57%, 57%, and 48% of normal breast tissue samples, respectively. This pattern of expression was also found in 100% of normal breast tissues using Ki67. (C) A proportion of normal breast tissues demonstrated a strong MCM2, MCM4, and MCM6 nuclear labeling in most if not all of the luminal cells lining the normal breast ducts (43%, 43%, and 52% of normal breast tissue samples, respectively).