MCM2, MCM4, and MCM6 expression in the different stages of progression of breast cancer.
Three representative cores showing three different stages of breast cancer (i.e., breast carcinoma in situ, invasive breast carcinoma, and lymph node metastasis) stained with HPS. Levels of MCM2, MCM4, and MCM6 expression exceed that of Ki-67 in the different stages of progression of breast cancer (the same tissue cores were stained with the four antibodies in consecutive sections prepared from the tissue microarray).