Table 8.
Correlation between the Four Markers on Comparing Each of the Three Scoring Schemes Using Intraclass Correlation Coefficient
| A. Immunohistochemical Scoring (IHS) | |||
|---|---|---|---|
| MCM4 IHS | MCM2 IHS | Ki-67 IHS | |
| MCM6 IHS | 0.828 [0.792-0.858] (<.0001) | 0.530 [0.434-0.611] (<.0001) | 0.73 [0.674-0.777] (<.0001) |
| MCM4 IHS | 0.514 [0.413-0.597] (<.0001) | 0.664 [0.594-0.723] (<.0001) | |
| MCM2 IHS | 0.386 [0.259-0.492] (<.0001) | ||
| B. Percentage Scoring (%) | |||
|---|---|---|---|
| MCM4% | MCM2% | Ki-67% | |
| MCM6% | 0.911 [0.892-0.926] (<.0001) | 0.861 [0.833-0.885] (<.0001) | 0.787 [0.742-0.823] (<.0001) |
| MCM4% | 0.864 [0.836-0.888] (<.0001) | 0.781 [0.735-0.819] (<.0001) | |
| MCM2% | 0.828 [0.793-0.858] (<.0001) | ||
| C. Visiomorph Tissuemorph Scoring (Vis. Tis. S.) | |||
|---|---|---|---|
| MCM4 Vis.Tis.S | MCM2 Vis.Tis.S | Ki-67 Vis.Tis.S | |
| MCM6 Vis.Tis.S | 0.913 [0.895-0.928] (<.0001) | 0.850 [0.819-0.875] (<.0001) | 0.741 [0.688-0.786] (<.0001) |
| MCM4 Vis.Tis.S | 0.846 [0.815-0.873] (<.0001) | 0.769 [0.720-0.809] (<.0001) | |
| MCM2 Vis.Tis.S | 0.715 [0.656-0.764] (<.0001) | ||
IHS: immunohistochemical score, %: percentage score, Vis. Tis. S.: Visiomorph Tissuemorph score.
ICC can be interpreted as follows:
0.0-0.2 indicates poor agreement;
0.3-0.4 indicates fair agreement;
0.5-0.6 indicates moderate agreement;
0.7-0.8 indicates strong agreement; and
>0.8 indicates almost perfect agreement.