Table 6.
Results of latent class model estimates (95% CI)
| Overall population without PCR prioritization (n = 214) | ||||
|---|---|---|---|---|
| All ages | Se | Spe | LR+ | LR− |
| Culture | 0.69 | 0.96 | 19.2 | 0.32 |
| Multiplex PCR assay | 1.0 | 0.97 | 33.3 | ∞ |
| Nga-PCR assay | 0.9 | 0.95 | 17.0 | 0.10 |
| Age ≤ 17 years | Se | Spe | LR+ | LR− |
| Culture | 0.75 | 0.99 | 109.1 | 0.25 |
| Multiplex PCR assay | 0.99 | 0.98 | 46.4 | 0.01 |
| Nga-PCR assay | 0.89 | 0.97 | 32.6 | 0.11 |
| Age > 17 years | Se | Spe | LR+ | LR− |
| Culture | 0.61 | 0.97 | 22.7 | 0.40 |
| Multiplex PCR assay | 1.0 | 0.98 | 41.7 | ∞ |
| Nga-PCR assay | 0.90 | 0.91 | 10.1 | 0.10 |
LR+ = positive likelihood ratio; LR− = negative likelihood ratio; PCR = polymerase chain reaction; Se = sensitivity; Spe = specificity. Estimates (CI = 95%) were calculated with MPlus software version 7.11. Without PCR prioritization means difference in volume (volume BC − volume PCR) ≥ −0.1mL. For computational reason, we selected only samples between 3 mL and 4 mL of blood for culture, eliminating, therefore, 36 samples.