Table 1.
Immunological Features of Patient with MGUS and SIgMD*
| Test | Results | Reference ranges |
|---|---|---|
| Serum Immunoglobulins (mg/dl) | ||
| IgM | 34 | 65-263 |
| IgA | 1,090 | 68-378 |
| IgG | 1,570 | 694-1,618 |
| IgG1 | 1,000 | 342-1,117 |
| IgG2 | 586 | 147-524 |
| IgG3 | 192 | 21-114 |
| IgG4 | 20 | 7-88 |
| IgE (IU/ml) | 316 | 10-150 |
| Autoantibodies | ||
| ANA (EIA units) | 28.4 | 0.2-12.0 |
| cANCA | Negative | Negative |
| dsDNA | Negative | Negative |
| Smith (ENA) | Negative | Negative |
| Thyroglobulin (U/ml) | 73.3 | 0.0-60.0 |
| Specific antibodies | ||
| Diphtheria Toxoid IgG (IU/ml) | 0.288 | >0.099 |
| Tetanus Toxoid IgG (IU/ml) | 0.728 | >0.150 |
| Strep. pneumoniae type 1 (ug/ml) | >20.0 | >1.0 |
| Strep. pneumoniae type 3 (ug/ml) | 5.5 | >1.0 |
| Strep. pneumoniae type 4 (ug/ml) | 12.9 | >1.0 |
| Strep. pneumoniae type 5 (ug/ml) | 0.8 | >1.0 |
| Strep. pneumoniae type 6B (ug/ml) | 1.0 | >1.0 |
| Strep. pneumoniae type 7F (ug/ml) | 13.8 | >1.0 |
| Strep. pneumoniae type 8 (ug/ml) | 6.8 | >1.0 |
| Strep. pneumoniae type 9N (ug/ml) | 3.5 | >1.0 |
| Strep. pneumoniae type 9V (ug/ml) | 1.2 | >1.0 |
| Strep. pneumoniae type 12F (ug/ml) | <0.2 | >1.0 |
| Strep. pneumoniae type 14 (ug/ml) | >20.0 | >1.0 |
| Strep. pneumoniae type 18C (ug/ml) | 16.8 | >1.0 |
| Strep. pneumoniae type 19F (ug/ml) | >20.0 | >1.0 |
| Strep. pneumoniae type 23F (ug/ml) | 1.7 | >1.0 |
| Antimicrobial antibodies (IgG) | ||
| H. pylori | Positive | Negative |
| Antistreptolysin O (IU/ml) | 323.0 | <200 |
| Complement | ||
| CH50 (U/ml) | 52.0 | 22-60 |
| C2 (mg/L) | 14.4 | 6.0-32.5 |
| C4 (mg/dl) | 15.0 | 15.0-45.0 |
| Immunofixation | IgAλ | None |
| Urine free light chains | ||
| Free κ light chain (mg/dl) | 11.90 | 1.35-24.19 |
| Free λ light chain (mg/dl) | 1.51 | 0.24-5.66 |
| κ/λ ratio | 7.89 | 2.04-10.37 |
*
At the initial diagnosis in 2008.