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. 2019 Aug 1;9(8):1734–1745.

Figure 3.

Figure 3

Wt-p53 did not regulate NOTCH1 signaling in GSCs. A. TP53 mutant was knocked out (KO) from GSC23. Then Wt-p53 was introduced into two p53KO subclones. Wt-p53 was also introduced into GSC293, which harbored innate wt-p53. The expression of p53 and NOTCH1 pathway components was detected by Western blot analysis. B. The expression of p53 and NOTCH1 pathway components was detected after Nutlin-3 treatment (24 hours) in two wt-p53 GSCs (GSC34 and GSC293) by Western blot analysis. n = 3. Blue font: wt-p53 cells. Red font: mut-p53 cells.