Table 1.
Summary of dysregulated snoRNAs and related cancer diseases
| SnoRNA ID | Dysregulation | Study models | Pathology | Function | Ref. |
|---|---|---|---|---|---|
| snoRA21 | ↑ | Sample from patients Cell lines: HCT116, SW480 | colorectal adenomas and cancers | proliferation, invasion, poor survival | [90] |
| snoRA23 | ↑ | Sample from patients | pancreatic ductal adenocarcinoma (PDAC) | regulates expression of SYNE2 to promote growth and metastasis | [91] |
| snoRD42 | ↑ | Sample from patients Cell lines: H226, H292, H460, A549, H1299, H1944, H358, H1792, SK-MES-1, H522 and BEAS-2B | Non-small cell lung cancer (NSCLC) | proliferation, colony formation | [26] |
| snoRD42 | ↑ | Sample from patients Cell lines: Caco2, HCT116, HT29, LoVo, SW480 and SW620 | colorectal cancer (CRC) | proliferation, migration, invasion, anoikis resistance and tumorigenicity | [27] |
| snoRD76, snoRD78 | ↑ | Sample from patients Cell lines: Caco2, HCT116, HT29, LoVo, SW480 and SW620 | CRC | [27] | |
| ACA11 | ↑ | Sample from patients Cell lines: Caco2, HCT116, HT29, LoVo, SW480 and SW622 | CRC | binds to heterogeneous nuclear ribonucleoproteins | [27] |
| snoRD33, snoRD66 | ↑ | Sample from patients | NSCLC | [36] | |
| snoRA55 | ↑ | Sample from patients Cell lines: PCa cell lines | prostate cancer (PCa) | proliferation, migration and poor prognosis | [92] |
| snoRD112-114 | ↑ | Sample from patients Cell lines: leukemic blast cells | acute promyelocytic leukemia (APL) | affects Rb/p16 cell cycle regulation to promote cell growth | [93] |
| RNU2 | ↑ | Sample from patients | pancreatic and colorectal adenocarcinoma | highly stable in serum and plasma | [37] |
| snoRD126 | ↑ | Sample from patients Cell lines: Huh-7, SW480 | hepatocellular carcinoma (HCC) and CRC | facilitates HCC and CRC cell growth via activating the PI3K-AKT pathway | [28] |
| HBII-289, U22, U3, U15b, U94, U97 | ↑ | Sample from patients Cell lines: MCF-7, MCF-10A, U-2OS, HCT-116, A549, RWPE1, Hela, U87 cells | breast and prostate cancer | modulation of p53 | [59] |
| snoRD115 | ↓ | Sample from patients | Prader-Willi syndrome (PWS) | regulates the alternative splicing of serotonin receptor 2 C | [94] |
| snoRD113-1 | ↓ | Sample from patients Cell lines: HepG2 and Huh7 | HCC | inactivates the phosphorylation of ERK1/2 and SMAD2/3 in MAPK/ERK and TGF-β pathways | [95] |
| snoRD76 | ↓ | Sample from patients Cell lines: U87-MG, LN229, U251, and SNB19c | glioblastoma (GBM) | inhibits proliferation and growth | [29] |
| snoRD50 | ↓ | Sample from patients Cell lines: Caco2-2, HCT116, HT29, LoVo, SW480 and SW620 | colon, breast and prostate cancers and B-cell lymphoma | inhibits K-Ras signaling pathway and inhibited proliferation and growth | [47] |
| snoRD123, U70c, ACA59B | ↓ | Cell lines: HCT116, normal colon mucosa cells | CRC | [43] |