Table 1.
Exosome mediate the cell communication in leukemia hematopoietic microenvironment
| RESOURCE | RECEIVE CELL | KEY MOLECULE | TARGET GENE | PATHWAY | FUNCTION | REFERENCE |
|---|---|---|---|---|---|---|
| AML | HUVECs | VEGF/VEGFR | --- | --- | Induce glycolysis, vascular remodeling and acquisition of chemoresistance | [8] |
| AML | BMSCs | --- | CXCR4 | Promote migration | [63] | |
| AML | BMSCs | --- | CXCR4, c-Kit | --- | Promote HSPC mobilization | [65] |
| AML | --- | --- | BCL-2 | --- | Therapy resistance | [71] |
| AML | MDSCs | --- | --- | IL-6/STAT3 signaling | Immunosuppressive activity | [75] |
| AML | NK cells | TGF-β1 | NKG2D | --- | Suppressed the immune functions | [77] |
| NB4 | ECs | --- | --- | --- | Procoagulant activity | [64] |
| drug-resistant CML | sensitive CML | miR-365 | pro-apoptosis proteins | --- | Drug resistance | [73] |
| CML | ECs | miR-210 | Ephrin-A3 | VEGF signaling | Decresed angiogenesis | [57] |
| K562 | ECs | pre-miR-92a | integrin a5 | --- | Promote cell migration, tube formation | [56] |
| K562 | BMSCs | --- | Cxcl12, DKK1, wnt5a, IL-6 | VEGF signaling | Decreased production of reactive oxygen species (ROS) | [59] |
| BCP-ALL | --- | IL-15 | --- | --- | Disruption of the blood brain barrier (BBB) | [66] |
| CLL | MSCs | --- | -- | AKT/ERK and NF-κB signaling | Induce inflammatory and protumorigenic environmental conditions | [67] |
| CLL | --- | miR-150, miR-155, and miR-223 | --- | --- | Associated with a poor CLL outcome | [69] |
| CLL | NK cells | --- | CD16, CD56 | --- | Suppressed cytotoxicity | [79] |
| APL | ECs | --- | --- | --- | Increased survival | [64] |
Note: leukemia cell derived exosmes affected the other cells of hematopoietic microenvironment via transfor a variety of content. ‘---’ means there are no detailed informations.