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. 2019 Aug 1;9(8):1830–1845.

Figure 3.

Figure 3

Human NSCLC cell lines are dependent on GCN5 and ADA2B functions. Genome-loss-of-function dependency data of human lung cancer cell lines were analyzed using RNAi and CRISPR screen datasets. (A) The breakdown of human lung cancer cell types dependent on GCN5 and ADA2B in the RNAi screen and (B) GCN5 or (C) ADA2B dependent cell lines and dependency scores were analyzed. Cell lines with dependency scores of ~ -0.3 or lower are represented. (D) The breakdown of human lung cancer cell types dependent on GCN5 and ADA2B in the CRISPR screen and (E) GCN5 as well as (F) ADA2B dependent cell lines and dependency scores were analyzed. Cell lines with dependency scores of ~ -0.3 or lower are represented. Lung cancer cell lines exhibiting a dependency for both GCN5 and ADA2B are underlined.