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. 2019 Aug 29;12:202. doi: 10.3389/fnmol.2019.00202

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Copyright © 2019 Chen, Meng, Bi, Li, Chang, Ji and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NEK7 knock-down alleviates NLRP3 inflammasome activation-induced K⁺-free medium. Primary cortical neurons were transduced with NC-shRNA or NEK7-shRNA, and treated with K⁺-free medium or normal medium. (A) Analysis of intracellular K⁺ in each condition. (B) IL-1β release was detected. (C) NEK7 and caspase-1 in the supernatant (Sup) and cell lysate (Lys) were analyzed. CoIP analysis of the interaction between NEK7 and NLRP3. Data are represented as the means ± SEM, n = 4. ***p < 0.001, vs. 5 mM group. ^###p < 0.001, vs. WT.