Table 2.

Comparison of pathologic characteristics between humans and large animal models.

	Human	Canine	Caprine	Ovine	Porcine	Lapine
Naturally occurring pathology	Common (40)	Common (41)	Uncommon	Uncommon	Uncommon	Maybe (subclinical) (42)
Time to development of DJD	10–20 years (2)	Weeks to months (43)	6–8 months (44, 45)	5 months (46)	4–6 weeks (47)	4–6 weeks (48, 49)