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. Author manuscript; available in PMC: 2020 Feb 4.
Published in final edited form as: Mol Pharm. 2019 Jan 16;16(2):808–815. doi: 10.1021/acs.molpharmaceut.8b01091

Figure 2. Metformin reduces renal uptake of 68Ga-NOTA-c(TNYL-RAW).

Figure 2.

(A) Representative coronal μPET/CT images of EphB4+ A375SM tumor–bearing mice acquired 1 h after intravenous injection of 68Ga-NOTA-c(TNYL-RAW). Arrows, kidney; T, tumor. (B) Biodistribution of 68Ga-NOTA-c(TNYL-RAW) 4 h after radiotracer injection. Metformin (48 mg/kg) or vehicle was co-injected with radiotracer. Data are presented as mean ± SEM. *p<0.05.