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Schematic of the tip functionalization process, in which three steps of reaction are required: the bare tip is first functionalized by (a) silanization and then (b) a SpyTag azide terminated peptide reacts with the alkyne group of the alkyne-PEG-silane (c) and eventually the SpyTag peptide reacts with the SpyCatcher terminated fusion protein forming a strong covalent isopeptide bond (d).
