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Permeation pathways in the “bricks and mortar” model for the stratum corneum. (A) Schematic representation of the skin layers (bottom). Adapted with permission from ref (678). Copyright 2014 Elsevier. The “bricks and mortar” model of the SC (top left) and its main components (top right) are also shown. (B) Full- and (C) low-hydration bilayer models used in MD simulations. Adapted with permission from ref (679). Copyright 2018 PCCP Owner Societies.
