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Schematic model for SNARE-mediated membrane fusion. The monomers of t-SNARE (I) assemble into the t-SNARE complex (II) and folds (III). The t-SNARE forms a complex with the v-SNARE (VAMP2), also binding synaptotagmin and Munc18. (IV) The complex formed by t- and v-SNARE zips up (V) and initiates fusion (VI). Reproduced with permission from ref (861). Copyright 2016 Zhang et al.
