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CG MD simulations capture how apoA-I stabilizes pleats formed on the outer leaflet due to different lipid densities between the leaflets. The left and right panels show the same configuration from two different angles. (A) First, a wedge-like structure forms, (B) which grows in time, (C) forming into a hemidisk. (D) ApoA-I wrapped disk connected to the bilayer with a stalk. Adapted with permission from ref (1247). Copyright 2015 Elsevier.
