Figure 70.

Mechanism of CL involvement in proton transfer in the cytochrome bc₁ dimeric complex. (A, left) CL molecule (cyan) and cytochrome bc₁ (CIII) dimer (cartoon) interface captured in MD. (A, right) The small figures show the divergent interactions of CL with nearby residues captured in different simulations. (B) Putative proton conduction pathways (magenta) mediated through waters and a lysine residue between the CL (cyan) and the water in the quinone-binding site. The protein is not shown, and the heme is shown in black. The right-most figure shows the same configuration as that on its left except colored based on the electrostatic potential (red, negative; blue, positive). Reprinted with permission from ref (1284). Copyright 2013 Elsevier.