Figure 8.

Schematic diagram showing location of GATA3 expression (green) in the embryonic and adult kidney. GATA3 is expressed by two major renal progenitor populations, ureteric bud and stromal cells, and continues to be expressed by all cell types that originate from them, i.e., epithelial cells of the CDs/DN/CN and stromal cell descendants (mesangial, VSMCs, renin-producing cells, and fibroblasts). Deficiency in GATA3 results in a paucity of MCs and smaller glomeruli, and increased GATA3 expression is associated with mesangial proliferative GN.