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. 2019 Jul 10;30(9):1659–1673. doi: 10.1681/ASN.2018121244

Figure 1.

Figure 1.

Mouse kidney EGFR expression is androgen-dependent. (A) Renal EGFR mRNA and protein levels were comparable between wild-type male and female mice at prepubertal 7 days of age. n=5. (B) Renal EGFR mRNA and protein levels were significantly higher in wild-type male than female mice at postpubertal 3 months of age (**P<0.01; n=4 in female group and n=5 in male group). (C) Oophorectomy (bilateral removal of ovaries) of wild-type female mice at age 21 days had no effect on renal EGFR expression 6 weeks later. n=4 in sham group and n=5 in ovariectomized group. (D) Castration of wild-type male mice at age 21 days led to decreased renal EGFR expression 6 weeks later (**P<0.01; n=5 in each group).