Figure 8.

Schematic representation of the steps and molecules involved in nuclear translocation of activated DDR1. (A) In unstimulated cells, DDR1 interacts with NM-IIA and β-actin at the plasma membrane (PM). (B) Upon collagen stimulation and DDR1 auto-phosphorylation (pY), DDR1/NM-IIA/β-actin complex interacts with Sec61B in the endoplasmic reticulum (ER). (C) This interaction promotes DDR1 nuclear translocation and its association to chromatin where, together with NM-IIA and β-actin, it promotes the transcription of collagen IV (CIV).