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IC50s for nintedanib in ECM accumulation assay for total and individual ECM markers
| IC50 geomean, μM | Nintedanib, range, μM | Number | |
|---|---|---|---|
| Total ECM proteins | 0.672 | 0.579–0.865 | 3 |
| Fibronectin | 0.882 | 0.797–1.273 | 3 |
| Collagens I and III | 0.421 | 0.134–0.855 | 3 |
| Collagen IV | 0.704 | 0.244–1.252 | 3 |
| Collagen V | 0.326 | 0.193–0.440 | 3 |
ECM, extracellular matrix.
